International Journal of Clinical Obstetrics and Gynaecology

Author(s): Dr. KL Malarvizhi, Dr. M Kavitha, Dr. M Indhuja and S Padmanaban

Abstract: Background: Pre eclampsia is a multi-system disorder specific to pregnancy and puerperiumwhich manifest by hypertension and proteinuria after 20weeks of gestation andresolves by 12 weeks after delivery. Preeclampsia is a multisystem disorder of pregnancy whose aetiology remains unknown. Although management is evidence based, past hypotheses and scientific contributions have influenced the understanding of pathophysiology of preeclampsia and guided its management. Aims & Objectives 1. To find if prolactin has a role in pathogenisis of pre eclampsia. 2. To estimate serum prolactin during 14-20 weeks of pregnancy. 3. To correlate serum prolactin levels during 14 -20 weeks of pregnancy as a predictor for pre eclampsia Materials & methods Type of study: Prospective observational study Period of Study: 6 months Place Of Study: Antenatal outpatient department& Antenatal Ward. Labour ward. Dept of Obstetrics & Gynaecology. Govt Kilpauk Medical College &Hospital, Chennai 10. Results: In my study mean prolactin level is 297.47 in pre eclampsia and 139.46 in healthy pregnant. This study shows statistically significantincrease in prolactin level in pre eclamptic women compared to healthy pregnant women. When the serum prolactin is 196 mg /dl sensitivity is .829 and 1- specificity is 000 and the youden index is maximum at that point .829. hence 196mg /dl is cut off value for predicting pr eclampsia. Based upon the statistical analysis sensitivity of the test is 82.85% and specificity is 100% and positive predictive value is 100% and negative predictive value is 92.11%. Coefficient of the agreement is .865671642 which is an excellent agreement. Conclusion: This study revealed raised level of prolactin in women with pre eclampsia compared to healthy pregnant. Still large number of study is required to conclude prolactin as marker of pre eclampsia.

DOI: https://doi.org/10.33545/gynae.2018.v2.i3b.81

Pages: 81-86 | 2136 Views | 1018 Downloads

Download Full Article: Click Here