Introduction: Despite considerable research, the pathophysiology of preeclampsia remains unclear. However, oxidative stress has been attributed to be the causative factor of preeclampsia. Uric acid is a marker of oxidative stress, tissue injury and renal dysfunction.
Aims and objectives: To study the association of raise in serum uric acid level in severe preeclampsia and to evaluate perinatal outcome in severe preeclampsia with raised serum uric acid.
Methodology: This is a prospective clinical observational study undertaken to study the significance of estimating serum uric acid in severe preeclampsia and perinatal outcome in severe preeclampsia and compare it with normotensive pregnant women. This study was conducted for a period of one year from October 2018 to September 2019 in the department of obstetrics and gynaecology, Vanivilas hospital, Bangalore.
Results: Mean serum uric acid in study group is 7.16mg/dl & in control is 3.52mg/dl. The difference in mean serum uric acid concentration between study and control group was found to be statistically significant (p<0.05). The highest mean serum uric acid concentration is in preterm study group (8.23mg/dl) followed by term study group (7.52mg/dl). The difference between them is statistically significant (p<0.05) In the study group the MSUA concentration is found higher in LBW & VLBW babies compared to normal birth weight babies & the difference in MSUA concentration was statistically significant in study group (p<0.05).