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International Journal of Clinical Obstetrics and Gynaecology

International Journal of Clinical Obstetrics and Gynaecology

Print ISSN: 2522-6614, Online ISSN: 2522-6622

International Journal of Clinical Obstetrics and Gynaecology

2020, Vol. 4, Issue 2, Part B

Ormeloxifene versus oral contraceptive pills in the management of DUB
Author(s): Dr. V Arunadevi and Dr. SNS Minnalkodi
Abstract: Background: DUB is defined as abnormal uterine bleeding without any clinically detectable pelvic pathology. The present study was conducted to compare the efficacy and safety of ormeloxifene and combined oral contraceptive pills in medical management of DUB.
Methods: 110 cases of DUB aged between 25 and 45 years were randomly assigned into two groups. Group A received Ormeloxifene 60mg twice a week for 3 months and then once a week for next 3 months. Group B received combined oral contraceptive pills (Levonorgestrel 0.15mg and Ethinylestradiol 20mcg) one tablet from the 5th day of menses for 21 days given for 6 cycles. Regular follow up was done to assess response, compliance and side effects of drug. The treatment was evaluated by measuring menstrual blood loss by PBAC (Pictoral Blood Loss Assessment Chart), Haemoglobin g/dl and endometrial thickness before and after treatment.
Results: Ormeloxifene was found to be significantly more effective (P< 0.0001) than OC pills in controlling menorrhagia. There was significant decrease in endometrial thickness and improvement in Haemoglobin level in ormeloxifene group.
Conclusion: Ormeloxifene is more effective and well tolerated than OC pills in treatment of DUB.
Pages: 81-85 | 596 Views | 71 Downloads
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How to cite this article:
Dr. V Arunadevi and Dr. SNS Minnalkodi. Ormeloxifene versus oral contraceptive pills in the management of DUB. International Journal of Clinical Obstetrics and Gynaecology. 2020; 4(2): 81-85. DOI: 10.33545/gynae.2020.v4.i2b.508
International Journal of Clinical Obstetrics and Gynaecology