To investigate the relation of 25, hydroxyvitamin D concentration and parathyroid hormone with insulin resistance in PCOS women.
Methods: A cross-sectional study was conducted on 50 PCOS (Rotterdam’s criteria) women. Concentrations of 25, hydroxyvitamin D and PTH were measured along with serum levels of fasting sugar and insulin. The homeostasis model assessment index was used as the insulin resistance index.
Results: Total prevalence of vitamin D deficiency (<20ng/ml) was found to be 84% while increased parathyroid hormone level was observed in 64%. There was significant negative correlation between vitamin D deficiency and HOMA-IR (r=-0.67, p<0.01). Positive association was found between increased PTH levels (normal levels: 13.9- 38.3pg/ml) and HOMA-IR.
Conclusion: Vitamin D deficiency and high parathyroid levels are associated with glucose intolerance in PCOS women. Strong correlation between vitamin D deficiency and insulin resistance in PCOS women may suggest that normalization of vitamin D levels may correct insulin resistance.