Abstract: Aim: The purpose of the study was to determine the accuracy of Pap smears and the correlation between Pap smear diagnoses and histopathology in order to evaluate the diagnostic efficacy of Pap smears for intraepithelial lesions.
Material and methods: This retrospective study, which included 100 Pap smears for which histopathological diagnosis was also performed, was conducted in the Department of Pathology at a tertiary care center. In addition to Pap smears, comprehensive clinical histories of patients were extracted from requisition forms received by the cytology department. Additionally, hysterectomies or cervical specimens obtained from the same patients were analyzed and subsequently correlated with the Pap smear diagnosis.
Results: A total of one hundred Pap smear-bearing patients (41 percent) were multipara and aged 45 years or older. The most frequently reported cases were NILM (59%), followed by ASCUS (15%), LSIL (14%), HSIL (7%), squamous cell carcinoma (3%) and adenocarcinoma (2%). Histopathological examination revealed the following diagnoses: chronic cervicitis (37% of cases), chronic cervicitis with squamous metaplasia (28% of cases), CIN I (25%), CIN II (3.0%), CIN III (2.0%), squamous cell carcinoma (2%), and adenocarcinoma (3% of cases). The diagnostic accuracy, positive predictive value, specificity, and sensitivity were as follows: 87%, 92.44%, 83.34%, 93.43% and 70% respectively.
Conclusion: The data suggests that Pap smears play a significant role in the diagnosis of cervical lesions, as the highest number of cases diagnosed on Pap smears exhibited correlation with histopathology.
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