Abstract: Background: Glanzmann thrombasthenia is a genetic disorder which is rarely seen in which the platelets have qualitative and quantitative deficiencies of fibrinogen receptor. Patients with Glanzmann thrombasthenia present with mucosal bleeding, petechaie, ecchymosis, menorrhagia, gastrointestinal bleeding. Presenting here a series of 3 cases of Glanzmann thrombasthenia who presented to obstetrics and gynaecology department with gynaecological complaints. One had a large ovarian haemorrhagic cyst and the other two had severe menorrhagia. All these three cases were managed conservatively.
Material and Methods: Retrospective Observational Study was conducted at a tertiary care centre over a period of 2 years in our unit. All the three patients were diagnosed with Glanzmann thrombasthenia with gynaecological complaints and their case record were analysed.
Results: We had total three cases of Glanzmann thrombasthenia presenting to gynaecology department. All were in adolescent age group. One had a large ovarian haemorrhagic cyst and the other two had severe menorrhagia. All three had severe anaemia due to blood loss. All required factor VII, platelets and blood transfusion and one required immunoglobulin. All cases were managed conservatively.
Conclusions: Patients with Glanzmann thrombasthenia present with spontaneous episode of bleeding, which can be severe and even life threatening. Medical management is the mainstay of treatment. Platelet transfusion is the recommended treatment. Newer modalities of treatment like factor VIIa may also be beneficial to these patients.
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