Preeclampsia (PE) is one of the main causes of maternal and fetal mortality and morbidity. It is a chief source of morbidity and mortality worldwide. PE is associated with an inflammatory state and with oxidative stress, in maternal circulation. Measuring the CRP and uric acid concentration in preeclamptic women could help in understanding the best course of action for the pregnant woman and the foetus, especially if there is an association between CRP levels and severity of preeclampsia.
Objective: To determine the levels of C-reactive protein and uric acid levels in preeclampsia pregnant and to determine severity by the association among CRP, uric acid concentration, BMI and blood pressure.
Method: This was a case-control study was conducted at Dept. of obstetrics and gynecology, Narayana medical college Hospital, including pregnant women. 25 PE cases and matched normal pregnants in third trimester were enrolled, clinical history and blood was collected to to assess CRP and Uric acid levels.
Results: The serum CRP and uric acid levels were found significantly higher in PE cases than normal pregnants. Uric acid and CRP levels were 5.39±1.76 mg% and 8.26±6.9 mg/l respectively in the study group (cases) compared with 3.72±1.29 mg% and 6.22±4.29 mg/l in controls. There was a positive correlation between CRP and mean arterial pressure and also between CRP and uric acid.
Conclusion: Serum uric acid and CRP may be feasible to be used as biomarkers for identifying women at risk of preeclampsia. The aetiology of preeclampsia is not well established but having more information about the condition will help in the monitoring and treatment of the pregnant to ensure her and her baby are well.