Abstract: Purpose: To compare the effect of oxytocin plus misoprostol versus oxytocin or misoprostol alone in reducing blood loss at ceasarean section.
Methods: This randomized control study included 126 primigravida patients undergoing lower segment cesarean section under spinal anesthesia and fulfilling selection criteria. Patients were randomly allocated to one of the three groups to receive 20 IU infusion of oxytocin (Group-O), 400 µg sublingual Misoprostol tablet (Group-M) or 200µg Misoprostol tablet plus 10 IU infusion of oxytocin (Group-M+O) after delivery. The main outcome measures-Blood loss, Heamoglobin values measured both before and 24 hr following surgery, adverse effects were recorded.
Results: There Mean blood loss during surgery was significantly less in combined lower doses of oxytocin plus misoprostol in compared to using higher doses of oxytocin and misoprostol alone (p<0.001). Mean haemoglobin changes significantly less in M+O group in compared to other group(P<0.001).
Conclusion: The combined use of lower dose of oxytocin plus misoprostol significantly decrease the amount of blood loss during and after cesarean section and minimal side effects compared to higher dose of oxytocin and misoprostol alone.
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