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International Journal of Clinical Obstetrics and Gynaecology

International Journal of Clinical Obstetrics and Gynaecology

Print ISSN: 2522-6614, Online ISSN: 2522-6622

International Journal of Clinical Obstetrics and Gynaecology

2018, Vol. 2, Issue 5, Part A

Predictive significance of serum Cystatin-C and serum lipids in preeclampsia
Author(s): Brijesh Mukherjee, Gargi Sarangi
Abstract: Introduction: Preeclampsia is a devastating pregnancy-associated disorder characterized by the onset of hypertension, proteinuria, and edema with limited plausible pathophysiology known. Cystatin-C, a novel marker for the detection of renal impairment, is increased in preeclampsia at an early stage. Moreover there is evidence of increased oxidative stress due to endothelial dysfunction in pre-eclampsia and increase in the oxidative stress is associated with abnormal lipid profile.
Objective: This study was aimed to evaluate the diagnostic efficiency of cystatin-C as an early marker of renal function and correlate with lipid profile in preeclampsia.
Materials and methods: The study was conducted on 80 pregnant women in third trimester who attended HMCH (O&G Department), Rourkela. They were divided in two groups A & B. Group A consisted of 40 normal pregnant women and Group B consisted of 40 pregnant women with preeclampsia. Lipid profile was done by auto analyzer using recommended kit and cystatin-C by immunoturbidrimetric method.
Results: Serum total cholesterol, LDL, HDL showed no significant change in the two groups (p>0.05). However serum triglycerides levels were found significantly higher in preeclampsia patients when compared to normotensive pregnant subjects. Similarly serum cystatin-C was significantly higher in group B (p<0.01) and showed good correlation with lipid profile.
Pages: 24-28 | 677 Views | 236 Downloads
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How to cite this article:
Brijesh Mukherjee, Gargi Sarangi. Predictive significance of serum Cystatin-C and serum lipids in preeclampsia. Int J Clin Obstet Gynaecol 2018;2(5):24-28.
International Journal of Clinical Obstetrics and Gynaecology