Background: Preterm Labour and delivery is one of the biggest challenges for obstetricians and any endeavor to reduce the perinatal mortality calls for a successful effort to reduce the problems of preterm birth for no single obstetrical misfortune is more wasteful as prematurity
In many instances, delaying delivery till the fetus is sufficiently mature is a tremendous gain for the fetus at no disadvantage to the mother. All that we have achieved so far is the possibility of gaining a few days with use of tocolytic agents our study is concerned with the Efficacy of Nifedepine – a calcium channel blocker as a tocolytic agent.
Aim: 1. To evaluate the Tocolytic effects of Calcium channel blocker – NIFEDIPINE in preterm labour.
2. To study the maternal and fetal effects of NIFEDIPINE
Materials and Methods: It is prospective study conducted I Government RSRM Lying in Hospital, Stanley Medical College, Chennai from September 2012 to September 2013 The study population comprised of patients who attended the causality or outpatient department. There were 100 patients in Nifedipine group and 2 patients were lost to follow-up. There were 100 patients in Central group and 3 patients were lost to follow up. Study group received Nifedipine and control group were observed with bed rest. Both groups received intra muscular corticosteroid written informed consent obtained.
Results: 1. In our study, Preterm labour was common in Primigravida in age group 20 – 29 years accounting for 77.54% compared to 22.5% between 19 and 30 years.
2. Incidence of preterm labour in looked and unbooked cases were 80.6% and 19.38% in Nifedipine group when compared to 86.5% and 13.4% in control groups respectively.
3. The success of Nifedipine as indicated by prolongation of pregnancy beyond 48 hours was observed in 73.4% of cases compared with 57% in controls P value was significant (< 0.001).
Conclusion: In developing countries neonatal intensive care are usually found in tertiary referral hospitals but not all such units have the required treatment capabilities. The statistically significant benefits of nifedipine in suppressing the uterine contractions for in utero transfer, in reducing neonatal respiratory distress syndrome along with its reduced maternal side effects, and its low cost makes it to be considered as the first line tocolytic agents in these countries.