International Journal of Clinical Obstetrics and Gynaecology
2019, Vol. 3, Issue 2, Part C
Serum C - reactive protein in normal pregnancy and preeclampsia- a comparative study
Author(s): Dr. Mohan Lal Meena, Dr. Kusum Meena, Dr. BS Meena and Dr. Chitra Gidwani
Abstract: The aim and objective of the study to find out association of C – reactive protein with pre-eclampsia, to find out CRP level in pre-eclampsia and to compare CRP level of pre-eclampsia with normal patients.as well as to study the level of C - reactive protein in relation to the severity of the preeclampsia and its pregnancy outcome. A Hospital based prospective comparative study was performed on 80 pregnant women in third trimester of pregnancy include 40 preeclamptic (20 mild and 20 severe) patients and 40 normotensive pregnant women as controls were selected for the study in the department of Obstetrics & Gynaecology, SMS Medical College & attached hospital, Jaipur from April, 2017 to October, 2018 for a period of one year After initial assessment of every patient, blood sample was collected in a sterile empty vial. Serum CRP levels were measured by high CRP sensitivity kit using Particle Enhanced Turbimetric Immunoassay (PETIA) Technique. Clinical outcome were evaluated. Statistical analysis was done using Student’s t-test. The mean level of serum CRP in preeclamptic patients was 15.4± 2.37 mg/dl and that in normotensive pregnant women was 2.68 ± 0.9 mg/dl (p-value < 0.0001). And mean level of serum CRP in mild preeclamptic patients was 13.22 ± 0.88 mg/dl and severe pre eclamptic patients was 17.58 ± 0.9 mg/dl (p<0.001). Our Study results showed that serum CRP levels were higher in pre-eclampsia patients than normotensive patients. CRP level was raised more in severe pre-eclampsia as compared to mild pre-eclampsia. CRP levels positively correlated with the severity of pre-eclampsia. Therefore, serum CRP level can be used as a utility parameter for the assessment of pre-eclampsia. These women can be monitored carefully as high risk cases thereby helping in early diagnosis and management of pre-eclampsia.
Dr. Mohan Lal Meena, Dr. Kusum Meena, Dr. BS Meena, Dr. Chitra Gidwani. Serum C - reactive protein in normal pregnancy and preeclampsia- a comparative study. Int J Clin Obstet Gynaecol 2019;3(2):141-145. DOI: 10.33545/gynae.2019.v3.i2c.25