Abstract: Background: The purpose of the study was to appraise the effectiveness and unfavorable side effects (if any) of an intravenous infusion of 1000 mg of acetaminophen during the active phase of labour.
Materials & Methods: The present study was conducted in the department of Obstetrics & Gynaecology of GMC Amritsar among 100 pregnant females. After obtaining the informed consent, and meeting the inclusion and the exclusion criteria, a total of 100 pregnant females were included in the present study and were broadly divided into two study groups, with 50 patients in each group, as follows:
Group 1: Patients received IV Acetaminophen (1000 grams).
Group 2: Patients receiving matched placebo. (100 ml normal saline) The duration of study was 1 and ½ year (April 2017 to October 2018). The course of events was studied and decrease in intensity of pain if any during labour was accessed by visual analog score and foetal outcome (i.e., Apgar score at 1 min to 5 min after birth).
Results: Mean duration of first stage of labour among females of the study group and control group was 417 minutes and 622.2 minutes respectively. Significant results were obtained while comparing mean VAS after 30 minutes and 60 minutes among females of the study group and the control group.
Conclusion: Intravenous acetaminophen is an effective intrapartum analgesic in both primigravida and multigravida women candidates, it also helps to reduce the duration of labour without any maternal and foetal adverse effects.
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