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International Journal of Clinical Obstetrics and Gynaecology

International Journal of Clinical Obstetrics and Gynaecology

Print ISSN: 2522-6614, Online ISSN: 2522-6622

International Journal of Clinical Obstetrics and Gynaecology

2019, Vol. 3, Issue 5, Part C

Pregnancy of unknown location- can serum creatinine phophokinase point towards tubal ectopic gestation?: A pilot study
Author(s): Sindhuja B and Jaya Vijayarghavan
Abstract: Background: Pregnancy of unknown location (PUL) is defined as the situation when the urine or serum pregnancy test is positive but there are no signs of intrauterine or extra-uterine pregnancy on ultra-sonography and serum beta HCG is in the window period. Among all possible outcomes of pregnancy of unknown location, ectopic pregnancy is the most feared outcome. A delay in diagnosis might increase the maternal mortality and morbidity.
Methods: A prospective observational study conducted at Sri Ramachandra Institute of Higher Education and Research, Chennai, between February 2018 and April 2019. Women who had beta HCG in the discriminatory zone with an inconclusive transvaginal ultrasound were included in the study. Serum Creatinine phosphokinase levels were measured along with beta HCG.
Results: Among the 12women with PUL, 11 of them were eventually diagnosed with ectopic gestation and one of them remained to be a pregnancy of unknown location. All the patients diagnosed with ectopic gestation had their initial serum CPK levels above the cut off value of 51IU/lit.
Conclusion: Serum CPK levels in PUL can be used as a marker for early diagnosis of ectopic gestation when beta HCG and ultrasound are inconclusive. Larger studies are required to ascertain the significance.
Pages: 155-157 | 721 Views | 122 Downloads
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How to cite this article:
Sindhuja B, Jaya Vijayarghavan. Pregnancy of unknown location- can serum creatinine phophokinase point towards tubal ectopic gestation?: A pilot study. Int J Clin Obstet Gynaecol 2019;3(5):155-157. DOI: 10.33545/gynae.2019.v3.i5c.345
International Journal of Clinical Obstetrics and Gynaecology