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International Journal of Clinical Obstetrics and Gynaecology

International Journal of Clinical Obstetrics and Gynaecology

Print ISSN: 2522-6614, Online ISSN: 2522-6622

International Journal of Clinical Obstetrics and Gynaecology

2019, Vol. 3, Issue 5, Part F

Comparison of methyldopa and labetalol in control of blood pressure in preeclampsia
Author(s): Dr. Suryarao Prashant Dwarkanath and Dr. Katakdhond Shriraj Shanmukh
Abstract:
Background: Preeclampsia is a leading cause of maternal and perinatal morbidity and mortality in developing world.
Materials and Methods: 188 eligible patients were randomly assigned to receive treatment with either labetalol or methyldopa.
Observation and Results: Proteinuria was drop down to 8.51 % after treatment with labetalol. There were 14 cases of IUGR in methyldopa group as compared to 4 cases in labetalol group. Patients with labetalol group delivered at term were 82.97 % whereas in methyldopa group 76.59%. There was no significant difference in Apgar score between two groups. Need of nicu in labetalol group was 6% as compared to 7% in methyldopa group. Drowsiness was the most common side effect observed in methyldopa group while very few cases of adverse effects in labetalol group.
Conclusion: our study suggests that labetalol is better than methyldopa in treatment of hypertension in pregnancy and has good perinatal and maternal outcome.
Pages: 372-379 | 1090 Views | 407 Downloads
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How to cite this article:
Dr. Suryarao Prashant Dwarkanath, Dr. Katakdhond Shriraj Shanmukh. Comparison of methyldopa and labetalol in control of blood pressure in preeclampsia. Int J Clin Obstet Gynaecol 2019;3(5):372-379. DOI: 10.33545/gynae.2019.v3.i5f.378
International Journal of Clinical Obstetrics and Gynaecology