Abstract: Background: PCOS is the common endocrine disorder with reproductive and metabolic dysfunction, which may get adversely affected in association with hypovitaminosis D. we studied vitamin D levels in PCOS women and correlation with metabolic parameters
. Materials and Methods: In this cross-sectional study, we enrolled 108 PCOS women, after excluding women, who were on insulin sensitisers, hormone therapy, vitamin D. Detailed history, physical examination findings were noted. Fasting blood sample was analysed for hormonal, biochemical Parameres and OGTT was done as per the standard protocol. Study subjects were categorized based on vitamin D levels into vitamin D deficiency (<20ng/ml), insufficiency (20-30ng/ml), sufficiency (>30ng/ml) groups and were compared for clinical and metabolic parameters using appropriate statistical tests and p< 0.05 was considered statistically significant.
Results: study population had a mean age of 24.99±5.07 years with a mean BMI of 28.1±4.67kg/m2. Hypovitaminosis D was found in 85.2% (deficiency in 62.96%, insufficiency in 22.2%) and normal vitamin D levels in 14.8% of the PCOS women. Impaired fasting glucose was found in10.2%, IGT in 15.7% and type2 diabetes in 4.63% women. Triglycerides, LDL-C were significantly higher and HDL-C were lower in women with hypovitaminosis D, with a significant negative correlation with triglycerides and no correlation with other metabolic parameters.
Conclusion: vitamin D deficiency is very common in PCOS women and may exacerbate the metabolic disturbances.
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