Effect of three different doses of letrozole in ovulation induction and its effect on gonadotropins dose in unexplained infertility
Author(s): Dr. Kainat Masroor and Prof. Bharti Maheswari
Abstract: Background/purpose: To evaluate the effect of three different doses of letrozole in ovulation induction and its effect on gonadotropins dose in unexplained infertility.Material and method: It was a prospective study conducted in the department of Obstetrics and Gynecology, Muzaffarnagar Medical College, Muzaffarnagar among 180 patients of infertility. Selected infertility cases were divided in three groups i.e. 1) Group 1(60 cases) infertile women treat with letrozole 2.5 mg, 2) Group 2 (60 cases) infertile women treat with letrozole 5 mg and 3) Group 3 (60 cases) infertile women treat with letrozole 7.5 mg. The demographic details of the subjects were recorded. All women were evaluated on the 2nd day of cycle with transvaginal ultrasound for measuring endometrial thickness and an antral follicle count as well as follicular vascularity. Base line that is on 3rd day of cycle serum FSH, LH levels were also measured in initial assessment. Group I, II and III received letrozole (Letrofem®; Iran hormone, Tehran, Iran) from day 3 of the cycle, 2.5 mg, 5mg, 7.5 mg orally per day for five days. Results: Maximum follicle and ET size was increased in subjects having letrozole 7.5 mg dose. Follicular number was 8 was reported among 70%, 68.33% and 61.67% of the subjects with 2.5mg, 5mg and 7.5mg letrozole dose respectively. Gonadotropin dose 1 and 2 was required by 45% and 35% of the subject’s 7.5mg letrozole dose respectively. Conclusion: We have shown that letrozole, used in doses greater than those commonly employed, can produce enhanced follicular growth without detrimental effects upon the endometrium.
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