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International Journal of Clinical Obstetrics and Gynaecology

International Journal of Clinical Obstetrics and Gynaecology

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Print ISSN: 2522-6614, Online ISSN: 2522-6622

International Journal of Clinical Obstetrics and Gynaecology

2020, Vol. 4, Issue 6, Part C

Comparison of empirical use of low dose aspirin alone and low dose aspirin plus low molecular weight heparine in the treatment of unexplained recurrent pregnancy loss
Author(s): Dr. Nitin Kulkarni and Dr. Akshay Jagtap
Abstract: Background: Unexplained Recurrent Miscarriage is a major women’s health problem. Recurrent pregnancy losses have commonly been defined as three or more consecutive spontaneous pregnancy losses. In 50-60% of cases of recurrent pregnancy losses, the cause remains unclear and known as unexplained/idiopathic recurrent pregnancy loss. It could be useful to use Aspirin, or Aspirin plus Heparin in women with unexplained recurrent miscarriage, which is believed to be caused by thrombosis in decidual vessels.
Objective: Objective of this study was to compare the maternal and fetal outcome in patients with unexplained recurrent pregnancy loss treated with LDA Vs LDA plus LMWH during pregnancy.
Method: An open clinical trial was conducted at the Department of Obstetrics and Gynecology at ACPM MEDICAL COLLEGE, DHULE from June 2019 to September 2020 to investigate the effects of treatment with low dose aspirin (LDA) alone versus LDA in combination with low-molecular-weight-heparin (LMWH) on patients with a history of recurrent miscarriages. We enrolled 150 women with history of three or more consecutive miscarriages in this study. Participants were randomly assigned to receive either LDA alone or a combination of LDA and LMWH. The primary outcomes were the rate of miscarriages and live births for each group.
Result: Regarding the primary outcome the two groups did not differ significantly. Four neonates in Group A and Three in group B were admitted in NICU. There were no congenital anomalies detected in either group. There was no significant difference observed in the mean birth weight of neonates born in either group.
Conclusion: Low dose Aspirin and Low dose Aspirin plus Low Molecular Weight heparin improves pregnancy outcome and increase rate of live birth without any significant differences.
Pages: 151-158 | 400 Views | 189 Downloads
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How to cite this article:
Dr. Nitin Kulkarni, Dr. Akshay Jagtap. Comparison of empirical use of low dose aspirin alone and low dose aspirin plus low molecular weight heparine in the treatment of unexplained recurrent pregnancy loss. Int J Clin Obstet Gynaecol 2020;4(6):151-158. DOI: 10.33545/gynae.2020.v4.i6c.747
International Journal of Clinical Obstetrics and Gynaecology