Study to compare the two different drug regimes in treatment of infertility among PCOS patients.
Materials and Methods: The present Randomized control trial was conducted in the Department of Obstetrics and Gynaecology, among PCOS patients diagnosed on the basis of revised Rotterdam 2003 criteria. In this clinical trial out of 120 patients, 60 patients received Clomiphene Citrate 100 mg (group A) and rest 60 patients received Letrozole 5mg (group B) daily since day 2-6 or 3-7 of menstrual cycle.
Result: Monofollicular development was statistically significantly, greater in the group B. There was also statistically significant difference between the two groups in endometrial thickness (CC 7.15±1.15mm, Let 9.31±2.15mm). Similarly, the ovulation rate was 88%% in group A and 92% in group B. The pregnancy rate was 23% in group A and 37% in group B.
Conclusion: The present study concluded that though Clomifen Citrate group showed good ovulation rate but final outcome was poor which can be due to anti-estrogenic effect resulting poor endometrial response and negative effect on cervical mucus.