We determined whether the use of etonogestrel subdermal contraceptive implant affects serum lipid indices.
Methods: Forty nine women with a mean age of 33.4±4.8years were enrolled into this prospective cross-sectional study with longitudinal follow up. After insertion of a single rod 68mg etonogestrel sub-dermal contraceptive implant, they were followed up for 6 months. Serum low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol and triglycerides were determined at insertion and 6 months post insertion and compared using Chi-square, Fisher’s exact and Student’s t-test as appropriate.
Findings: There was no reported contraceptive failure during the 6-month period. The mean serum total cholesterol, triglycerides, HDL and LDL values at 6-month post-insertion (170.82±51.77, 139.43 ± 44.05, 46.54 ± 6.53 and 125.58 ± 26.79 respectively) were all statistically significant higher than mean serum values at insertion (217.83± 44.62, 182.76± 37.07, 52.41±7.75, 149.02± 38.89 respectively) (p<0.001).
Conclusion: Our findings suggest that etonogestrel subdermal contraceptive implant may be associated with some increase in serum lipid values, within the first 6 months of insertion, in Nigerian women. However, this requires evaluation by further studies.
Funding: No funding sources