International Journal of Clinical Obstetrics and Gynaecology
2021, Vol. 5, Issue 4, Part E
Comparative study between uterotonics and tranexamic acid for the treatment of postpartum hemorrhage
Author(s): Maheshwari Marisiddaiah, Girija Kempasiddaiah and Bharatha Ratna
Abstract: Postpartum haemorrhage (PPH) is a major cause of maternal mortality, accounting for one-quarter of all maternal deaths worldwide. Uterotonics after birth are the only medical intervention that has been shown to be effective for PPH prevention and management. Tranexamic acid (TXA), an antifibrinolytic agent, has been investigated as a potentially useful complement to this for both prevention and treatment because its hypothesized mechanism of action in PPH supplements that of uterotonics and because it has been proved to reduce blood loss in normal delivery and caesarean section. This is a prospective observational study done during Dec 2018 to Dec 2020. 200 pregnant women who were booked in this hospital and delivered vaginally and clinically diagnosed with postpartum hemorrhage were taken for the study. 100 patients received standard protocol with placebo and 100 received standard protocol with Tranexamic acid 1 gm iv. Mean blood loss was 750 ml +/- 100 ml in standard protocol, whereas in Tranexamic acid it was 650ml +/- 100 ml. 2 patients required surgical intervention in standard protocol group, whereas no patients required surgical intervention in Tranexamic acid group. TXA is not a new drug and is generally well tolerated without any thrombogenic side effects.
Maheshwari Marisiddaiah, Girija Kempasiddaiah, Bharatha Ratna. Comparative study between uterotonics and tranexamic acid for the treatment of postpartum hemorrhage. Int J Clin Obstet Gynaecol 2021;5(4):267-269. DOI: 10.33545/gynae.2021.v5.i4d.995