Manuscript Writing Service
International Journal of Clinical Obstetrics and Gynaecology

International Journal of Clinical Obstetrics and Gynaecology

Login     Signup
Print ISSN: 2522-6614, Online ISSN: 2522-6622

International Journal of Clinical Obstetrics and Gynaecology

2021, Vol. 5, Issue 4, Part E

Evaluation of letrozole in infertile women with polycystic ovarian syndrome
Author(s): Dr. Ramesh C Patel and Dr. Mukund B Patel
Abstract:
Introduction: Ovulation dysfunction is one of the most common causes (prevalence 30-40%) of infertility. PCOS is one of the common cause of infertility. Letrozole is a potent, non stetoidal, aromatase inhibitor which is currently being used as ovulation inducing agent with few side effects. The aim is use of Letrozole as a first line ovulation inducing agent in polycystic ovarian syndrome (PCOS) as an alternative other commonly used ovulation induction agent.
Methods: Total 220 patients of PCOS were included in the study. Diagnosis of PCOS was made on Rotterdam criteria. All patients received 2.5 mg Letrozole daily since day 2-6 of cycle. Human chorionic gonadotrophin was administered at a dose of 5,000 IU when at least 1 mature follicle (17-25mm) was detected. Timed intercourse was advised to the patients after 24-36 hrs of hCG. Then the number of follicles, endometrial thickness, ovulation rate & pregnancy rate were measured.
Results: In this study 95.45% patients ovulated on first cycle, mono follicular development was significant greater in majority (86.4%) and only 2 patients developed mild OHSS, with good endometrial response, majority developed ET > 7.1mm. Out of 220 patients, 42 patients conceived out of which 14 had miscarriage, 10 had ectopic pregnancy.
Conclusion: Letrozole can be used as a first line drug to induce ovulation and pregnancy in PCOS patients.
Pages: 277-280 | 170 Views | 88 Downloads
Download Full Article: Click Here
How to cite this article:
Dr. Ramesh C Patel, Dr. Mukund B Patel. Evaluation of letrozole in infertile women with polycystic ovarian syndrome. Int J Clin Obstet Gynaecol 2021;5(4):277-280. DOI: 10.33545/gynae.2021.v5.i4e.998
International Journal of Clinical Obstetrics and Gynaecology