Background: Hypertensive disorders complicate upto 5-10% of pregnancies, 3.9% is preeclampsia the leading cause of both direct maternal and perinatal mortality. Mostly preeclampsia is diagnosed only after pathological changes are already established. The study being carried out to investigate the significance of urinary calcium-creatinine ratio in predicting the outcomes with hypertensive disorder of pregnancy.
Methods: All women between the gestational ages 20 -28 weeks were taken into the study, spot urine sample was taken to measure the urinary calcium-creatinine-ratio. Ratio less than or equal to 0.04 was considered test positive and those with ratio of >0.04 was considered test negative.
Results: 218 normotensive, 17Gestational hypertension, and 21 Preeclampsia were recruited fir the study. Urinary creatinine excretion among gestational hypertension and preeclampsia is more than normotensive women. Calcium excretion is low in preeclampsia compared to normotensive women. CCR was positive 87.69% of preeclampsia and 40% in gestational hypertension. We found that CCR was a better predictor of preeclampsia than gestational hypertension, with sensitivity of 73.81%, specificity of 95.18%.More maternal complications such as abnormal Doppler studies and HELLP syndrome among preeclampsia, and lower birth weight were noted among women with preeclampsia. More number of abnormal APGAR at 1’ and 5’ were noted in preeclampsia group.
Conclusion: Spot Urine calcium-creatinine ratio of ≤0.04 in asymptomatic pregnant women between 20-28 weeks of pregnancy is a good predictor for hypertensive disorders of pregnancy, especially preeclampsia. We can also conclude that there is increased maternal and fetal morbidity among women complicated with hypertension than normotensive women.