Background: To compare the value of methyldopa against labetalol among two groups of patients in pregnancy induced hypertension (PIH).
Methods: 150 women with PIH were divided into 2 groups to receive either labetalol (group A) or methyldopa (group B).The doses in both groups were modified as per requirement, to maintain diastolic blood pressure<100mmHg.Modification was done for better outcome of the study; keeping the maximum dose of Labetalol at 1200mg /day and methyldopa at 2gm/day. The data was collected by observation and measurement of various clinico-biochemical parameters. The statistical level of significance was taken at <0.05.
Result: It was seen that group A less prone to developed thrombocytopenia(2.6% vs 10.7%), alteration of liver enzyme (2.6% vs 8%), dearranged Coagulation profile (2.6%vs9.3%).More number of women developed headache and drowsiness in group B than group A (37.2% vs 25.6%) and (25.6%vs12.8%) respectively. In antenatal period both groups had good DFMC (87% vs 82%), with very less incidence of pathological CTG in intra partum period (12%vs16%). None of drug had any direct effect in improving peninatal outcome.
Conclusion: Labetalol has quicker action, more efficacious to control blood pressure. Better maternal outcome with lesser development of complication is found with labetalol. None of this drug (Labetalol and Methyldopa) had only edge over the other with respect to perinatal outcome.