Abstract: Introduction: Hypertensive disorders of pregnancy complicate 5-10 percent of all pregnancies
[1]. It occurs mainly because of vasospasm and vascular endothelial malfunction that occurs after 20 weeks of gestation. Preeclampsia is a condition characterised by hypertension with proteinuria or hypertension with multiorgan involvement. It is one of the causes of maternal mortality and morbidity and also affects fetal outcomes. In this study we are going to know the association of increased homocysteine levels with severity of pre eclampsia and its fetal outcomes.
Materials and Method: We conducted a case control study in a semi urban setting in tamilnadu to find the association of serum homocysteine levels in preeclampsia and normotensive pregnancy and its correlation with severity of preeclampsia. 100 women with singleton pregnancy and gestational age of 28-40 weeks were selected into study and control group consecutively as and when they presented. After a detailed clinical history and examination and routine blood investigations were taken along with 5ml blood for serum homocysteine levels.
Observation and Results: Serum homocysteine levels were measured in both cases and control groups and was found to significantly raised among patients with preeclampsia. Serum homocysteine levels were raised depending upon the severity of preeclampsia. There was statistically significant difference found between mild and severe preeclampsia cases in homocysteine values who delivered IUGR babies. (p value <0.05).
Discussion: Serum homocysteine levels were raised in 96% of the cases diagnosed with preeclampsia. Comparison of homocysteine based on perinatal outcomes in different groups showed that there was statistical significance in raise of serum homocysteine levels in women who delivered IUGR babies.
Conclusion : Our study concluded that serum homocysteine levels were significantly raised in cases with preeclampsia and the levels of homocysteine directly correlated with severity of preeclampsia. The study also concluded that serum homocysteine levels were raised in cases who presented with various maternal complications and those who had IUGR babies.
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