To assess the influence of sperm parameters on pregnancy outcomes in cases which had ovulation induction (OI) with clomiphene citrate (CC) or recombinant gonadotropin and underwent intrauterine insemination (IUI) for unexplained infertility and male factor indications.
Materials and Methods: 183 patients with diagnosed male infertility and 196 patients with unexplained infertility who presented to the infertility outpatient clinic of our hospital between June 2015 and June 2018 underwent OI with CC or gonad.
Results: 377 cycles were analyzed, 181 in the male infertility group (Group 1) and 196 in the unexplained infertility group (Group 2) were examined. There were 17 (9.4%) pregnancies in Group 1 and 22 (11.2%) in Group 2 (p:0.559). Clinical pregnancy was found in 7.7% (14 subjects) of group 1 and 11.2% (22 subjects) of group 2. Before washing, the sperm count of 39 pregnant patients was 61±30.6 million/ml. Due to the absence of data from two patients after washing, the sperm count of 37 patients analyzed after washing was 58.7±34.8 million/ml, and the difference between pregnancy and sperm count before and after washing was statistically significant (p:0,001). The percentage of progressive sperm motility of 39 pregnant patients was 43.5%±11.5% before washing. Since the data of 2 patients were not collected after washing, the percentage of progressive sperm motility of 37 patients evaluated after washing was 64.4±13.5%, and it was statistically significant that sperm motility after washing had a positive effect on pregnancy (p:0.001). otropin and IUI, and the pregnancy outcomes of the patients were retrospectively analyzed. The criteria for female partners in both groups were to be younger than 38 years, to have an ovulatory cycle, and to have at least one open tube. Semen parameters of male partners were assessed according to the thresholds of the 2010 World Health Organization criteria (WHO).
Conclusion: Pregnancy rates after OI and IUI are similar in male infertility and unexplained infertility, regardless of treatment option. However, to determine the fertilization potential of a semen sample, more powerful tests than standard semen analysis are required.