The aim of the study was to compare the glycemic control and maternal outcome among gestational diabetic women treated with metformin versus insulin.
Methodology: A prospective observational study conducted in the obstetrics and gynecology department of post graduate teaching hospital, after obtaining approval from Institutional Ethics Committee. The diagnosis of the GDM was confirmed by two step approach according to American Diabetes Association (ADA) guidelines. Participants who diagnosed with GDM were given with dietary counselling and advised for moderate physical exercise. Repeated the Fasting Blood Sugar (FBS) and Post Prandial Blood Sugar (PPBS) after two weeks. Those with FBS greater than 120 mg/dl and PPBS greater than 140 mg/dl, were referred to a physician to confirm the diagnosis and to start with appropriate drug treatment.
Result: Among 3972 pregnant ladies visited in the obstetrics and gynecology department during the study period, 286 were diagnosed to have GDM. Out of 286 GDM patients, 140 were treated with insulin and 146 were treated with metformin. The overall result from the study says that metformin was found as effective as insulin in controlling glycemic status in GDM women; also metformin was found to be effective in reducing maternal complications when compare to that of insulin treated group.
Conclusion: The study conclude that metformin is a cost-effective oral hypoglycemic agent, which may be a more logical alternative to insulin for women with GDM.