Abstract: Background: Sickle cell anemia is autosomal recessive single gene defect in the ß-globin chain of HbA. Women with sickle cell disease are at greater risk of morbidity and mortality in pregnancy.
Objectives: To study the effect of Sickle cell Disease over the course of pregnancy, its outcome and management.
Method: It is a Hospital based observational prospective study conducted at Obstetrics and Gynaecology department Government medical college, Nagpur over a period of 18 months in 80 pregnant females having SCD attending OPD or admitted.
Result: An observational prospective study in pregnant females having SCD showed 22.5% Anaemia cases, 12.5% preeclampsia and cases for PROM was 2%. The Pre-term labour cases were seen only 5% and IUGR cases of 7%. The Birth Weight with <1.5kg was 5%, birth weight between 1.5-2.5 kg were 50% and birth weight greater than 2.5kg were 45%. The NICU Admission was 30%. Past history of crisis was seen in 15% of cases. Vaso-Occulusive Crisis was 6.3% and the hemolytic crisis was 6.3%. The Acute Chest Syndrome was 2.5%. Conclusion: Comprehensive care may promote awareness of Sickle Cell Disease among affected women to present early for booking, assessment and management of symptoms.
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