Abstract: Introduction: One of the most prevalent medical conditions during pregnancy is hypertensive disorders of pregnancy (HDP), which is also one of the leading causes of maternal and perinatal morbidity and mortality globally. This study was carried out to correlate the elevated liver function test (LFT) and serum beta HCG observed in the early second trimester with the increased maternal and foetal morbidity and mortality associated with HDP.
Material and Method: The Rajkiya Manila chikitchalay JLN Medical college Ajmer's department of obstetrics and gynaecology conducted this hospital-based observational study. 375 pregnant women with a gestational period longer than 20 weeks were used in the correlation study between LFT and beta HCG and HDP, with 250 pregnant women with HDP serving as the study group and 125 pregnant women without hypertension serving as controls. Serum-HCG levels and LFT were tested and their levels in the two groups were compared.
Results: In the 25-year-old age group and younger, severe pre-eclampsia was observed. In hypertension cases, the likelihood of developing severe preeclampsia was 78%. The incidence was 88 percent in patients with elevated LFTs. The maternal mean serum levels of Beta-HCG in the HDP study group (51161.08±30038.21 IU/L) were greater than those in the control group with normal blood pressure (17603.23±16748.21 IU/L). The mean blood levels of non-severe preeclampsia were 36417.32±23876.74 IU/L and severe preeclampsia were 60030.34±28771.31 IU/L. Higher amounts were seen in early-onset preeclamptic moms compared to late-onset preeclamptic mothers, which was statistically significant (p<0.001). 32077 IU/L was the cut-off mark for beta-HCG with a sensitivity of 65% and a specificity of 86% for predicting HDP.
Conclusions: HDP women have greater serum levels of beta-HCG than normotensive women. Increased severity of hypertensive disorders during pregnancy is linked to higher levels of beta-HCG. Due to its low sensitivity and difficulties in determining the cut-off value, serum beta-HCG has limited application as a diagnostic test. In contrast to severe pre-eclampsia with normal LFTs, detection of elevated LFTs in cases of severe pre-eclampsia is a risk group linked to a higher rate of feto-maternal problems.
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