Abstract: Preeclampsia is a pregnancy specific disorder in which hypertension and proteinuria occurs after 20 weeks of gestation. Preeclampsia and other hypertensive disorders of pregnancy are a leading cause of maternal and infant illness and dead. But the exact pathophysiology is yet to be explored. Maternal vitamin D deficiency during pregnancy may be an independent risk factor for preeclampsia. The objective of this study is to explore the association of maternal serum vitamin D with preeclampsia. The aim of the study is to evaluate the association of maternal serum vitamin D level with preeclampsia. A cross sectional comparative study carried out in the Department of Obstetrics and Gynecology at Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka for a period of twelve months. A total of 60 women between 28 to 37 complicated weeks of gestation were included in this study. Among them, 30 pregnant woman with preeclampsia were included as group-I and rest 30 pregnant woman without preeclampsia were served as group-II. After all aseptic precaution, 6 ml of fasting blood sample were collected from all the study subjects for estimation of serum vitamin D. Containers of urine samples were collected for estimation of urinary protein. All data were recorded, processed and plotted in tabular and figure form. Statistical analyses of the results were obtained by using window based computer software devised with Statistical Packages for Social Sciences (SPSS-22). The mean age was 27.00±3.54 years in group I and 26.23±3.5 years in group II. The mean BMI was 26.09±6.05 kg/m² in group I and 24.12±2.81 kg/m² in group II. The difference of BMI was statistically significant (p<0.05) between two groups. More than half (53.3%) patients belonged to vitamin D level <10 ng/ml in group I and 5(16.7%) in group II. The mean vitamin D level was 9.77±1.98 ng/ml in group I and 12.78±3.01 ng/ml in group II. The difference was statistically significant (p<0.05) between two groups. A negative significant Pearson's (r=-0.384; p=0.002) between serum vitamin D level with systolic blood pressure. Another negative significant Pearson's (r=-0.366; p=0.004) between serum vitamin D level with diastolic blood pressure. The study concluded low maternal serum Vitamin D level increases the risk of preeclampsia.
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