Abstract: Introduction: Oxidative stress (OS) and mitochondrial dysfunction play a crucial role in the etiology of male infertility. Coenzyme Q10 (CoQ10) is a potent antioxidant and mitochondrial bio-energizer that improves semen parameters in infertile men. The use of CoQ10 with various other antioxidants has also shown a beneficial effect in enhancing sperm parameters.
Objective: To investigate the effectiveness and tolerability of a unique combination of ubiquinol, L-carnitine, zinc, lycopene and astaxanthin in male patients with infertility.
Methods: It was a multicenter, prospective, observational, real-world evidence study involving 79 doctors who enrolled 648 male patients with infertility. Patients received a study product once daily for three months. Semen analysis was done at baseline and the end of the treatment. A change from baseline in semen volume, sperm concentration, sperm motility and sperm morphology were analyzed.
Results: The treatment with our study product for a mean duration of 2.90 months showed a significant improvement in semen volume (17.85%; p= 0.003), sperm concentration (42%; p<0.0001), sperm motility (43.62%; p= 0.0014) and sperm morphology (20.34%; p<0.0001) as compared to baseline.
Conclusion: A novel blend of ubiquinol, L-carnitine, zinc, lycopene and astaxanthin for three months demonstrated a significant improvement in sperm parameters and should be considered as a treatment option for the management of male patients with infertility.
Indexed in Index Copernicus
