Abstract: Background: Ovarian tumour preferably malignant one is the leading cause of morbidity and mortality. Despite advancement in surgical and chemotherapeutic treatment during the last decade, still survival rates are poormainly due to late and incidental diagnosis.
Objective: To find out correlation of raised serum CA-125 level with laparotomy and histopathological findings of ovarian tumours.
Methodology: This prospective study was conducted in the department of Obstetrics & Gynaecology in Rangpur Medical College & Hospital, Rangpur from July 2017 to June 2018. Total 30 patients having ovarian tumour were diagnosed clinically and by ultrasonography were included in the study was serum CA-125 was estimated in all study subjects.
Results: Total 30 cases of ovarian tumour with raised serum CA-125 were enrolled in the study. Out of 30 cases 11(36.67%) were benign tumours& 19(63.33%) were malignant tumour. Majority of the patients were in the age group of41 to 60 years. The mean age±SD in benign tumour was 34.45±12.42 years and in malignant tumour was a 50.21±17.99 years. Age ranged from 14 to 70 years. Lump in the abdomen 86.7% was the commonest presentation. The commonest tumour was epithelial tumour 27(90%) followed by germ cell tumour 3(10%).Serous cyst adenoma (63.3%) was common benign tumour & serous cyst adenocarcinoma was the commonest malignant variety (26.3%). CA-125 level markedly raised (>300U/ml) in 46.7% cases and majority were malignant.
Conclusion: As serum CA-125 is markedly raised in malignant ovarian tumour so we can conclude raised serum CA-125 is a useful tumour marker as prognostic purpose of ovarian malingnancies.
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