Abstract: Introduction: Hypertensive disorders seem to complicate approximately 10% of pregnancies and are important causes of maternal and fetal morbidity and mortality. It is estimated that globally 6-8% of pregnancies are complicated by hypertension. It is said that preeclampsia and eclampsia contribute to the death of a women every 3 minutes worldwide.
Objective: To asses and compare the efficacy of labetalol and methyldopa in controlling blood pressure in patients with pregnancy induced hypertension.
Methods: This study was conducted in the Department of Obstetrics and Gynaecology, Islami Bank Medical College Hospital, Rajshahi, Bangladesh from March 2021 to February 2023. 120 patients with PIH were divided in to two groups randomly. After randomization, group A received methyldopa 250 mg tid and group B received labetalol 100mg tid. A common method used to estimate the MAP is the following formula: MAP = DP+1/3(SP –DP) or MAP = DP+1/3(PP). Patients were subjected to 6hrly BP monitoring. Comparison of two drugs were done daily by calculating MAP of two groups. Following Observations were made as regards fall in BP with Labetalol/ Methyldopa, Time required to control BP, Average dose of drugs required to control BP, Onset of labour-spontaneous/induced, Bishop Score at induction of labour, Side effects of drugs.
Results: Total 120 patients, maximum number of patients that is 60 patients belonged to the age group of 15 to 24 years: 32 patients (53.3%) are in Group A and 30 patients (50.0%) are in Group B. The mean age of the patients in Group A was 24.41yrs and in group B was 24.85yrs. The mean age was statistically non-significant in both the groups. Significant fall in MAP was seen in patients receiving Labetalol. Mean time required to control B.P in group A was 42.22 hours and in group B it was 36.97 hours. Mean Bishop score at induction in present study in group A was 8.27 and in group B was 9.33 with a statistically significant p<0.05. 6(33.3%) patients went in spontaneous labour in group A while in group B, 16 patients i.e. (48.5%) patients went in spontaneous labour.
Conclusion: The study concluded that the use of labetalol to reduce blood pressure in pregnancy induced hypertension patients is significantly effective than methyl dopa along with advantage of spontaneous onset of labour.
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