Abstract: Background: Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorder among the women in reproductive age. Based on the diagnostic criteria the prevalence of PCOS varies from 3% to 22%. Application of various diagnostic methods also has wide variations in detecting the presence of PCOS. Hence a reliable method to predict and diagnose PCOS in clinical and biochemical settings remains warranted.
Objective: To see the efficacy and safety of oral Apremilast in patient with moderate to severe plaque type psoriasis with reduction of PASI from baseline.
Method: This cross-sectional analytical study was carried out in the Department of Obstetrics and Gynae, Sir Salimullah Medical College & Mitford Hospital, Dhaka. 80 sample will be included in the within the age range of 15 to 45 years attending the OPD during the study period; among them 40 were diagnosed cases of PCOS and the reminder without PCOS. Serum C Reactive Protein (CRP), serum Albumin and Leukocyte Count were carried. Statistical analysis was carried out using the Statistical Package for Social Sciences (SPSS).
Results: Mean age was 23.78±2.90 years and 24.03±2.62 years in PCOS and non PCOS group respectively. There was no significance difference in age between two groups. There was no significance difference in BMI, waist circumference, systolic BP and diastolic BP between two groups. Serum CRP, serum CRP/albumin, WBC, neutrophils, lymphocytes and monocytes found significantly higher in PCOS than non PCOS. Albumin level was found significantly lower in PCOS than non PCOS. The area under the curve for CRP/albumin: 0.941, 95% CI 0.896 to 0.987; for WBC 0.764, 95% CI 0.656 to 0.872. According to this ROC curve, a cut off value 0.089 of Serum CRP/Albumin was found which can differentiate PCOS from non PCOS with 90.0% sensitivity and 82.5% specificity. Similarly a cut off value of 5050 cell/cm3 of WBC was found which can differentiate PCOS from non PCOS with 80.0% sensitivity and 65.0% specificity.
Conclusion: CRP/albumin ratio is a good biomarker in differentiating PCOS from non PCOS. WBC have also good association with PCOS but CRP/albumin ratio have stronger association with PCOS.
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