Abstract: Synchronous endometrial and ovarian cancer (SEOC) is a rare genital tract tumour. It should be differentiated from primary endometrial or ovarian tumours with metastasis since the two entities have different therapeutic and prognostic implications. In this review we present a case of woman who was diagnosed with SEOC, and discuss the clinical characteristic of SEOC, diagnostic and molecular profiling issues Next generation sequencing of 10 gene panel was performed on cancerous tissue and uterine lavage samples.