Abstract: Introduction: Polycystic ovary syndrome (PCOS) a heterogeneous disorder, characterized by hyperandrogenism, chronic anovulation, obesity, and insulin resistance (IR). Studies have demonstrated the beneficial effect of vitamin D supplementation on insulin resistance in PCOS.
Aim: To find the difference of vitamin D level between the PCOS and control groups. And to correlate serum 25(OH)D concentration and metabolic risk factors in PCOS women.
Materials and Methods: 49 women, diagnosed with PCOS were recruited as cases and another 49 women without PCOS served as controls. Demographic data like age, BMI, menstrual pattern, clinical features like hirsuitism, acne were recorded for both cases and control. The serum 25(OH)D and metabolic markers were measured. The primary outcome was the difference in vitamin D status between the cases and controls, the secondary outcomes were correlations between serum 25(OH)D concentration and metabolic risk factors in women with PCOS.
Results: Vitamin D level was significantly lower in cases than in controls (p<0.05). The prevalence of IR was significantly greater in the Vitamin D deficiency group among cases (p<0.05), but not so for BMI and fasting insulin. Also, prevalence of obesity and deranged lipid profile was not significantly increased in the vitamin D deficiency group of PCOS patients.
Conclusions: Vitamin D deficiency is prevalent in PCOS women with Insulin Resistence and with metabolic risk factors like HDL - C. Larger sample sizes are needed to probe correlation with other metabolic risk factors in PCOS women.
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