Abstract: Background: Infertility, affecting 8–12% of reproductive-age couples globally, is often exacerbated by metabolic abnormalities such as insulin resistance, dyslipidemia, thyroid dysfunction, and hyperprolactinemia. These factors disrupt hormonal balance, impair ovulation, and reduce pregnancy success rates, particularly in sub-fertile women.
Aim of the study: To investigate the impact of correcting metabolic dysfunctions on ovulation and pregnancy rates in sub-fertile women.
Methods: This prospective analytical study was conducted at the Department of Obstetrics and Gynaecology, Khulna Medical College and two others Private Hospitals, Khulna, Bangladesh over three years, from January 2021 to December 2023. A total of 120 sub-fertile women aged 18–45 years were included. Baseline and follow-up assessments of metabolic parameters—BMI, blood glucose, lipid profile, thyroid function, and serum prolactin—were performed, with targeted interventions implemented to address abnormalities. Ovulatory function was monitored after three and six menstrual cycles. Data analysis was conducted using SPSS, with p<0.05 considered statistically significant.
Result: The intervention significantly improved metabolic and hormonal parameters. Mean TSH levels decreased from 7.42±2.09 to 3.12±1.05 mIU/L (p<0.001), and serum prolactin levels dropped from 25.36±5.24 to 14.82±4.09 ng/mL (p<0.001). Estradiol levels increased to 52.89±13.27 pg/mL (p<0.05), and progesterone rose to 5.62±1.21 ng/mL (p<0.001). Ovulation was achieved in 66.67% of participants within three cycles and 8.33% within six cycles, demonstrating a marked improvement in reproductive outcomes.
Conclusion: Metabolic correction plays a pivotal role in improving ovulatory function and pregnancy rates in sub-fertile women. Addressing metabolic dysfunctions through targeted interventions should be an integral component of fertility management, offering promising outcomes for women seeking to conceive.