International Journal of Clinical Obstetrics and Gynaecology

Author(s): Vidya Chaudhary, Mimansa Bharti and Shivani Rawat

Abstract: We report the case of a 29-year-old pregnant woman who developed acute kidney injury (AKI) during her third trimester while receiving carbimazole for hyperthyroidism, with TI-RADS 3 colloid nodules in the left thyroid lobe. The patient exhibited symptoms consistent with hyperthyroidism, and carbimazole therapy was initiated at 3 months of gestation. Over the course of her pregnancy, a gradual elevation in serum creatinine was observed, from a baseline of 0.8 mg/dL to a peak of 2.59 mg/dL, accompanied by bilateral grade 2 medical renal disease by the 37th week. Carbimazole was discontinued at 37 weeks gestation, followed by delivery twelve days later. Postpartum follow-up revealed progressive improvement in renal function, with complete resolution of renal complication by two weeks. This case highlights the possible mechanisms of carbimazole-induced nephrotoxicity and emphasizes the need for close renal monitoring in pregnant patients receiving antithyroid therapy and to better manage subclinical hyperthyroidism.

DOI: https://doi.org/10.33545/gynae.2025.v9.i5a.1683

Pages: 40-42 | 297 Views | 67 Downloads

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