International Journal of Clinical Obstetrics and Gynaecology
2025, Vol. 9, Issue 5, Part B
Noninvasive prenatal testing (NIPT) advanced-uses and limitations-a review article
Author(s): Saswati Mukhopadhyay
Abstract: Noninvasive prenatal testing (NIPT), or noninvasive prenatal screening (NIPS), determines the risk of fetal chromosomal aneuploidies. When the chromosome number is more or less than standard (46), the fetus is called aneuploidic and will show abnormality, both structural and functional. The pregnant mother’s bloodstream contains a mix of cell-free DNA (cfDNA) made up of both maternal and placental cells. The DNA of placental cells and fetal cells is usually identical. Analyzing placental cfDNA allows early screening of the fetus for chromosomal anomalies.
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