International Journal of Clinical Obstetrics and Gynaecology
2025, Vol. 9, Issue 6, Part B
A rare case of ovarian Sertoli-Leydig cell tumour (Androblastoma) presenting with virilization in an adolescent female
Author(s): Tanvi Chaudhary and Sayali Kulkarni
Abstract: Ovarian Sertoli-Leydig cell tumours are exceptionally uncommon neoplasms in the paediatric and adolescent population, accounting for less than 0.5% of all ovarian malignancies. These tumours typically manifest with clinical manifestations of androgen excess, particularly virilization. This case report describes a 14-year-old adolescent presenting with primary amenorrhoea, progressive virilization, and elevated serum androgens. Comprehensive diagnostic evaluation incorporating hormonal profiling, chromosomal analysis, advanced imaging, and histomorphologic examination revealed a unilateral ovarian Sertoli-Leydig cell tumour of intermediate differentiation. Fertility-sparing surgical intervention via laparoscopic salpingo-ovariotomy was undertaken successfully. Histopathologic confirmation and immunohistochemical phenotyping were consistent with SLCT. Following multidisciplinary tumour board review at the National Cancer Grid, close observation without adjuvant chemotherapy was recommended for this stage IA malignancy. Post-operative surveillance demonstrated normalisation of hormonal parameters, restoration of menses, and clinical remission at two years follow-up without radiologic evidence of recurrence. This case emphasises the diagnostic challenges, fertility preservation principles, and importance of multidisciplinary management strategies in adolescent patients with rare sex cord-stromal ovarian neoplasms.
Tanvi Chaudhary, Sayali Kulkarni. A rare case of ovarian Sertoli-Leydig cell tumour (Androblastoma) presenting with virilization in an adolescent female. Int J Clin Obstet Gynaecol 2025;9(6):116-119. DOI: 10.33545/gynae.2025.v9.i6b.1735
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