International Journal of Clinical Obstetrics and Gynaecology

Author(s): Zainab Raja and Shubhanshi Rathore

Abstract:

Background: Eclampsia remains a leading cause of maternal morbidity and mortality, and magnesium sulphate is the anticonvulsant of choice. Debate persists regarding the optimal dosing regimen, particularly in resource-limited settings.

Aim: To compare the efficacy and safety of the low-dose Solapur magnesium sulphate regimen with the standard Pritchard regimen in managing eclampsia and imminent eclampsia.
Material and Methods: A prospective comparative study of 70 women allocated to either regimen assessed seizure control, maternal outcomes, toxicity, and perinatal results. Data were analyzed using SPSS, with p < 0.05 considered significant.

Results: Both regimens achieved comparable seizure control and perinatal outcomes. The Pritchard regimen produced significantly higher serum magnesium levels and more toxicity events.
Conclusion: The Solapur regimen is equally effective and associated with fewer adverse effects, making it a safe alternative in resource-constrained environments.

DOI: https://doi.org/10.33545/gynae.2025.v9.i6h.1792

Pages: 1320-1324 | 122 Views | 51 Downloads

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