International Journal of Clinical Obstetrics and Gynaecology
2025, Vol. 9, Issue 6, Part J
A rare case of ovarian steroid cell tumor with atypical presentation: A Diagnostic challenge
Author(s): Raksha V Gaikar, Sudeep N Sambharam and Vrunda V Choudhary
Abstract: Steroid cell tumors are a rare subset of ovarian sex cord-stromal tumors, constituting less than 0.1% of all ovarian neoplasms. They are usually androgen-secreting and frequently present with virilizing symptoms, making diagnosis relatively straightforward. However, atypical presentations can pose diagnostic challenges. We report two cases of benign steroid cell tumors in reproductive-aged women, both presenting with secondary amenorrhea. One patient exhibited classical virilization, while the other demonstrated markedly elevated testosterone levels without any signs of virilism. Both underwent staging surgery with preservation of the contralateral ovary. Histopathology confirmed steroid cell tumor, not otherwise specified (NOS), with immunohistochemical positivity for Inhibin A, Androgen Receptor (AR), Melan A, and/or Calretinin. Postoperative testosterone levels normalized promptly. These cases highlight the clinical variability of ovarian steroid cell tumors and underscore the importance of thorough endocrine evaluation and histopathological confirmation.
Raksha V Gaikar, Sudeep N Sambharam, Vrunda V Choudhary. A rare case of ovarian steroid cell tumor with atypical presentation: A Diagnostic challenge. Int J Clin Obstet Gynaecol 2025;9(6):1480-1483. DOI: 10.33545/gynae.2025.v9.i6j.1819
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