Objective: To evaluate the efficacy of carbetocin versus oxytocin for prevention of postpartum haemorrhage in women undergoing vaginal delivery and caesarean section at a tertiary care hospital in North India.
Methods: This institution-based analytical comparative study with prospective design divided 174 randomly selected mothers with full-term singleton pregnancies admitted in KNMH in order to undergo delivery, into 2 groups. Group A was given a bolus dose of 100 mcg of carbetocin via IV after the delivery of the baby. Group B was given 20 IU oxytocin, 10 IU via IM and 10 IU in 500 ml of NaCL solution via IV route. Primary outcome were amount of blood lost during delivery (ml) and Drop of mean serum haemoglobin levels at 48 hours after delivery (gm%). p-value of <0.05 was considered to be statistically significant.
Results: Oxytocin group had a statistically significant higher quantity of blood loss (583.2+/- 118.8 ml) as compared to carbetocin group (539+/-142.6 ml) (p-value- 0.031) and a higher drop of mean Haemoglobin level at 48 hours as compared to carbetocin group (p-value-<0.001)
Conclusion: Carbetocin was found to be a better drug than oxytocin in preventing postpartum haemorrhage among North Indian mothers delivering via either vaginal delivery or caesarean.
International Journal of Clinical Obstetrics and Gynaecology
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